Snoring and obstructive sleep apnoea (OSA) are increasingly common conditions, and confer a significant health and socioeconomic burden.Furthermore, untreated OSA represents a significant mortality risk.Patients require careful assessment, including detailed clinical history and examination, sleep study and drug-induced sleep endoscopy (DISE).Altho
Chaperonin GroEL (Cpn60) requires cofactor GroES (Cpn10) for protein refolding in bacteria that possess single groEL and groES genes in a bicistronic groESL operon.Among 4,861 completely-sequenced prokaryotic genomes, 884 possess duplicate groEL top genes and 770 possess groEL genes with no neighboring groES.It is unclear whether stand-alone groEL
Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a well-studied ER-associated degradation pathway, or ERAD.In contrast, very little is known about post-ER quality control mechanisms for damaged or misfolded integral membrane proteins.Here we describe a quality control function of the Rsp5-ART ubiquitin lig
This research is intended to provide an initial solution to the problem of finding images for processing by photogrammetry in special cases where these do not exist.An overview of existing artificial intelligence-based algorithms that enable the extension of source image dataset is reported.In particular, this research focused on the use of prompt-
The increasing urban sprawl has contributed to the extensive fragmentation and reduction of natural habitat worldwide.Urbanization has a range of adverse effects on ecosystem functioning, including the disruption of plant dispersal processes across the landscape.Urban fragmentation can alter the distance and directionality of dispersal, leading to